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Fig. 2 | BMC Methods

Fig. 2

From: De Novo Rational design of peptide-based covalent inhibitors via mapping of complementary binding site residues – technical protocol and case study on KRASG12C and BTK481C

Fig. 2

Graphical illustration of the design of peptide-based covalent inhibitors. (A) Incorporation of a reactive warhead (blue) in the peptide scaffold (light purple) enables (B) the formation of covalent bond (red) between the modified peptide scaffold (dark purple) and the nucleophilic residue (green) near the active site (brown) of the protein target

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BMC Methods

ISSN: 3004-8729

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