Table 1 Filtered peptide sequences generated from KRASG12C and their predictive physiochemical characteristics, propensity of in vivo aggregation, and conformationally stable energy values
Peptide ID | Peptide Sequence | SVM Score | Toxicity prediction | Hydrophobicity | Amphipathicity | pI | Mol. Wt | Na4vSS | sOPEP Energy |
|---|---|---|---|---|---|---|---|---|---|
18 | RLKDH | -1.02 | Non-Toxin | -0.69 | 1.51 | 9.10 | 667.83 | -76.70 | -1.91 |
51 | KVHDR | -1.02 | Non-Toxin | -0.69 | 1.51 | 9.10 | 653.80 | -73.20 | -2.17 |
40 | HVKDR | -1.00 | Non-Toxin | -0.69 | 1.51 | 9.10 | 653.80 | -72.40 | -1.54 |
17 | KLHDR | -0.98 | Non-Toxin | -0.69 | 1.51 | 9.10 | 667.83 | -77.50 | -2.19 |
52 | HLKDR | -0.97 | Non-Toxin | -0.69 | 1.51 | 9.10 | 667.83 | -76.70 | -1.55 |
13 | RVKDH | -0.92 | Non-Toxin | -0.69 | 1.51 | 9.10 | 653.80 | -72.40 | -1.78 |