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Table 2 Characteristic features of the peptide sequences generated from KRASG12C after electrophilic warhead incorporation showing the position of modification, the chemical structure of warhead and constraint and restraint scores after covalent bond formation

From: De Novo Rational design of peptide-based covalent inhibitors via mapping of complementary binding site residues – technical protocol and case study on KRASG12C and BTK481C

  1. X represents the peptide position mutated for warhead attachment.
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BMC Methods

ISSN: 3004-8729

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